THE FIRST APPROVED PH1 TREATMENT FOR PATIENTS OF ALL AGES AND STAGES OF KIDNEY FUNCTION*1-4

OXLUMO® (lumasiran) is indicated for the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary oxalate (UOx) and plasma oxalate (POx) levels in children and adults. OXLUMO acts at the liver, the site of oxalate production. Overproduction of oxalate is the primary cause of disease manifestation in PH1.1-4

In clinical trials, OXLUMO was evaluated in both pediatric and adult patients, including those with an estimated glomerular filtration rate (eGFR) ranging from 8.6 mL/min/1.73 m2 to ≥90 mL/min/1.73 m2 and patients on hemodialysis.1,5

In clinical trials, OXLUMO was evaluated in both pediatric and adult patients, including those with an estimated glomerular filtration rate (eGFR) ranging from 8.6 mL/min/1.73 m2 to ≥90 mL/min/1.73 m2 and patients on hemodialysis.1,5

Tell Me About OXLUMO Tell Me About PH1

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*Alnylam is proud to feature real patients in our advertising. Patients may or may not be on an Alnylam therapy.
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Person with PH1*

Alnylam is proud to feature real patients in our advertising. Patients may or may not be on an Alnylam therapy.

Treatment with OXLUMO led to powerful reduction in 24-hour urinary oxalate in patients with PH11

Treatment with OXLUMO resulted in a 53% reduction in 24-hour UOx excretion from baseline to month 6 (primary endpoint for ILLUMINATE-A) for OXLUMO compared to placebo in a double-blind clinical trial of 39 patients ≥6 years with eGFR ≥30 mL/min/1.73 m2.†1,3

Least squares mean reduction averaged over months 3 through 6, corrected for BSA (OXLUMO, 65%; placebo, 12%); 95% CI: 45, 62; P<0.0001 vs placebo.

Show Me the Data

The dosing regimen for OXLUMO led to a rapid reduction in 24-hr UOx within 2 weeks, which was sustained through 24 months*1,3,6

OXLUMO is a subcutaneous injection dosed by weight.

Show Me the Dosing Regimens

In ILLUMINATE-A: OXLUMO demonstrated reduction in 24-hr UOx excretion from baseline to month 6 compared to placebo.

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Person With PH1 Disease
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WANT TO SPEAK WITH AN OXLUMO REPRESENTATIVE?

Our representatives are available to provide detailed information about OXLUMO and how it may help your patients with PH1.

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There’s more to learn about OXLUMO

When you sign up, we will keep you informed with updates and resources.

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Alnylam Assist® provides support services for patients throughout their treatment with OXLUMO.

Alnylam Assist® includes patient services in 4 key areas, including understanding insurance benefits and financial assistance options for eligible patients,* helping ensure access to therapy, and providing PH1 disease education.

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Patients must meet specified eligibility criteria to qualify for assistance. Alnylam reserves the right to make eligibility determinations and to modify or discontinue the program at any time.

1. OXLUMO Prescribing Information. Cambridge, MA: Alnylam Pharmaceuticals, Inc. 2. Lieske J, Sellier-Leclerc A-L, Shasha-Lavsky H, et al. Poster presented at ASN Kidney Week; November 2-5, 2023; Philadelphia, PA. 3. Garrelfs SF, Frishberg Y, Hulton SA, et al. N Engl J Med. 2021;384(13):1216-1226. 4. Sas DJ, Magen D, Hayes W, et al. Genet Med. 2022;24(3):654-662. 5. Michael M, Groothoff JW, Shasha-Lavsky H, et al. Am J Kidney Dis. 2023;81(2):145-155.e1. 6. Lieske J, Groothoff JW, Frishberg Y, et al. Presented at: National Kidney Foundation Spring Clinical Meetings; April 6-10, 2022; Boston, MA.

IMPORTANT SAFETY INFORMATION

Adverse Reactions
The most common (≥20%) adverse reaction reported in patients treated with OXLUMO was injection site reaction. Injection site reactions included erythema, swelling, pain, hematoma, pruritus, and discoloration.

Pregnancy and Lactation
No data are available on the use of OXLUMO in pregnant women. No data are available on the presence of OXLUMO in human milk or its effects on breastfed infants or milk production. Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for OXLUMO and any potential adverse effects on the breastfed child from OXLUMO or the underlying maternal condition.

INDICATION

OXLUMO is indicated for the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary and plasma oxalate levels in children and adults.

For additional information about OXLUMO, please see the full Prescribing Information.