DOSING &
ADMINISTRATION
Grace*Person with PH1

*Alnylam is proud to feature real patients in our advertising. Patients may or may not be on an Alnylam therapy.

Flexible administration with OXLUMO® (lumasiran)—at home or in the office

Some patients may qualify for at-home injections, administered by a healthcare professional, if covered by insurance.

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Oxlumo Administration

 

 

 

 

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Oxlumo Administration

 

 

 

 

 

After 4 initial monthly doses, patients ≥10 kg can receive OXLUMO quarterly1

Convenient quarterly or monthly (for patients <10 kg) ongoing administration by a healthcare professional helps ensure correct dosing and long-term adherence.1

3 starting doses: 3 mg/kg administered monthly

Month 1

3mg/kg dose

Month 2

3mg/kg dose

Month 3

3mg/kg dose

Ongoing dosing: 3 mg/kg administered quarterly, with the first ongoing dose administered 1 month after the last starting dose

Month 4

3mg/kg dose

Month 5

No dose

Month 6

No dose

Month 7

3mg/kg dose

Ongoing quarterly dosing continues past month 7

3 starting doses: 6 mg/kg administered monthly

Month 1

6mg/kg dose

Month 2

6mg/kg dose

Month 3

6mg/kg dose

Ongoing dosing: 6 mg/kg administered quarterly, with the first ongoing dose administered 1 month after the last starting dose

Month 4

6mg/kg dose

Month 5

No dose

Month 6

No dose

Month 7

6mg/kg dose

Ongoing quarterly dosing continues past month 7

3 starting doses: 6 mg/kg administered monthly

Month 1

6mg/kg dose

Month 2

6mg/kg dose

Month 3

6mg/kg dose

Ongoing dosing: 3 mg/kg administered monthly, with the first ongoing dose administered 1 month after the last starting dose

Month 4

3mg/kg dose

Month 5

3mg/kg dose

Month 6

3mg/kg dose

Month 7

3mg/kg dose

Ongoing monthly dosing continues past month 7

Download the Dosing Guide
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WANT TO SPEAK WITH AN OXLUMO REPRESENTATIVE?

Our representatives are available to provide detailed information about OXLUMO and how it may help your patients with PH1.

Let's Connect

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There’s more to learn about OXLUMO

When you sign up, we will keep you informed with updates and resources.

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Alnylam Assist™ Logo

Alnylam Assist® provides support services for patients throughout their treatment with OXLUMO

Alnylam Assist® includes patient services in 4 key areas, including understanding insurance benefits and financial assistance options for eligible patients,* helping ensure access to therapy, and providing PH1 disease education.

Let's Get Started

Patients must meet specified eligibility criteria to qualify for assistance. Alnylam reserves the right to make eligibility determinations and to modify or discontinue the program at any time.

1. OXLUMO Prescribing Information. Cambridge, MA: Alnylam Pharmaceuticals, Inc.

IMPORTANT SAFETY INFORMATION

Adverse Reactions
The most common (≥20%) adverse reaction reported in patients treated with OXLUMO was injection site reaction. Injection site reactions included erythema, swelling, pain, hematoma, pruritus, and discoloration.

Pregnancy and Lactation
No data are available on the use of OXLUMO in pregnant women. No data are available on the presence of OXLUMO in human milk or its effects on breastfed infants or milk production. Consider the developmental and health benefits of breastfeeding along with the mother’s clinical need for OXLUMO and any potential adverse effects on the breastfed child from OXLUMO or the underlying maternal condition.

INDICATION

OXLUMO is indicated for the treatment of primary hyperoxaluria type 1 (PH1) to lower urinary and plasma oxalate levels in children and adults.

For additional information about OXLUMO, please see the full Prescribing Information.